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A build-up of acetylcholine in the synaptic cleft, due to the inhibition of cholinesterase, means the neurotransmitter continues to act on the muscle fibre, so that any nerve impulses are effectively continually transmitted.
Sarin acts on cholinesterase by forming a covalent bond with the particular serine residue at the active site.
Biperiden, a synthetic acetylcholine antagonist, has been suggested as an alternative to atropine due to its better blood–brain barrier penetration and higher efficacy.
an enzyme that degrades the neurotransmitter acetylcholine after it is released into the synaptic cleft.
Exposure is lethal even at very low concentrations, where death can occur within one to ten minutes after direct inhalation of a lethal dose, People who absorb a non-lethal dose, but do not receive immediate medical treatment, may suffer permanent neurological damage.
It is generally considered a weapon of mass destruction.
Sarin in blood is rapidly degraded either in vivo or in vitro.In vertebrates, acetylcholine is the neurotransmitter used at the neuromuscular junction, where signals are transmitted between neurons from the central nervous systems to muscle fibres.